Cyclic beta-glucans at the bacteria-host cells interphase: One sugar ring to rule them all.
Guidolin, L. S., Arce-Gorvel, V., Ciocchini, A. E., Comerci, D. J. and Gorvel, J. P.
Instituto de Investigaciones Biotecnologicas Dr. Rodolfo A. Ugalde, Instituto Tecnologico de Chascomus, Universidad Nacional de San Martin, IIB-INTECH CONICET, Buenos Aires, Argentina.
CNRS, INSERM, CIML, Aix Marseille Univ, Marseille, France.
Comision Nacional de Energia Atomica, CNEA, Grupo Pecuario, Centro Atomico Ezeiza, Buenos Aires, Argentina.
Cyclic beta-1,2-D-glucans (CbetaG) are natural bionanopolymers present in the periplasmic space of many Proteobacteria. These molecules are sugar rings made of 17 to 25 D-glucose units linked exclusively by beta-1,2-glycosidic bonds. CbetaG are important for environmental sensing and osmoadaptation in bacteria, but most importantly, they play key roles in complex host-cell interactions such as symbiosis, pathogenesis, and immunomodulation. In the last years, the identification and characterisation of the enzymes involved in the synthesis of CbetaG allowed to know in detail the steps necessary for the formation of these sugar rings. Due to its peculiar structure, CbetaG can complex large hydrophobic molecules, a feature possibly related to its function in the interaction with the host. The capabilities of the CbetaG to function as molecular boxes and to solubilise hydrophobic compounds are attractive for application in the development of drugs, in food industry, nanotechnology, and chemistry. More importantly, its excellent immunomodulatory properties led to the proposal of CbetaG as a new class of adjuvants for vaccine development.
Cellular Microbiology 20(6): e12850 (2018)