Evaluation of Toxoplasma gondii recombinant antigens for early diagnosis of congenital toxoplasmosis.
Rivera, E. M., Moscatelli, G., Ballering, G., Ganuza, A., Alonso, A. M., Moroni, S., Clemente, M., Altcheh, J. and Angel, S. O.
Laboratorio de Parasitologia Molecular, INTECH, Consejo Nacional de Investigaciones Cientificas (CONICET)-Universidad Nacional General San Martin (UNSAM), Buenos Aires, Argentina.
Servicio de Parasitologia y Chagas, Hospital de Ninos "Ricardo Gutierrez", Gallo 1330 (C1425EFD), Buenos Aires, Argentina; Instituto Multidisciplinario de Investigaciones en Patologias Pediatricas (IMIPP)- CONICET-GCBA.
Servicio de Parasitologia y Chagas, Hospital de Ninos "Ricardo Gutierrez", Gallo 1330 (C1425EFD), Buenos Aires, Argentina.
Laboratorio de Biofabricas y Vacunas, INTECH, Consejo Nacional de Investigaciones Cientificas (CONICET)-Universidad Nacional General San Martin (UNSAM), Buenos Aires, Argentina.
Laboratorio de Parasitologia Molecular, INTECH, Consejo Nacional de Investigaciones Cientificas (CONICET)-Universidad Nacional General San Martin (UNSAM), Buenos Aires, Argentina. Electronic address: sangel@intech.gov.ar.
The performance of Toxoplasma rGra8, rMic1, and the chimeric rGra4-Gra7 antigens for early congenital toxoplasmosis (CT) diagnosis was evaluated. Sera from CT patients showed high IgG reactivity to rMic1, rGra8, and rGra4-Gra7. The seroreactivity of samples from uninfected infants was lost within 2 months of age.
Diagnostic Microbiology and Infectious Disease 102(3): 115608 (2022)